The “entourage effect” is a term used to describe the synergistic interaction of all the compounds present in cannabis, including cannabinoids, terpenes, and flavonoids. While THC and CBD are the most popularly known cannabinoids, the entourage effect maintains that these compounds interact better together than they do in isolation.
First described in 1998 by researchers Raphael Mechoulam and Shimon Ben-Shabat, the entourage effect illustrates how the full spectrum of cannabis compounds augments therapeutic effects and minimizes potential side effects. Examples include how CBD is known to modulate THC’s psychoactive effects, potentially diminishing any feelings of anxiety or paranoia.
Terpenes are the aromatic compounds that give cannabis its distinct flavors and smells. They, too, play a critical role in the entourage effect. In their interaction with cannabinoids, these compounds-myrcene, limonene, and pinene, to name a few-drive the overall experience. Myrcene, for example, may heighten THC’s sedative effects, whereas limonene could foster a more uplifting, energetic high.
A major reason many cannabis consumers and medical patients prefer full-spectrum or broad-spectrum products to isolates is because of something called the entourage effect. Full-spectrum products retain the complete chemical profile of the plant, including minor cannabinoids and terpenes. The broad-spectrum, on the other hand, excludes THC but keeps other compounds.
Understanding the entourage effect helps users make more informed choices in seeking relief from pain, anxiety, and insomnia, or even just a more balanced recreational experience. It underlines the complexity of cannabis and the possible benefits derived from holistic consumption.
