THCV is one of the lesser-known endogenous cannabinoids found within both cannabis and hemp plants. Unlike its better-known cousin THC (tetrahydrocannabinol), the way that THCV works in the body highlights a set of other benefits unique within the cannabinoid family.
Due to the structural similarity with THC, THCV binds to the same cannabinoid receptors in the endocannabinoid system. Its effects, however, can be quite different: low doses inhibit CB1 receptors, which means a very clear-headed experience without the psychoactive effects of THC being as potent. In higher doses, THCV is likely to act as a CB1 agonist, hence showing some mild psychoactive effects.
Perhaps most notably, THCV is an appetite suppressant and has been termed “diet weed.” This is in contrast to THC, which notoriously gives people the “munchies.” THCV may also support metabolic health, improve energy levels, and even help with glucose regulation, making it a subject of interest in those who study diabetes and obesity.
In addition to its metabolic benefits, THCV has shown preclinical promise in reducing anxiety, promoting bone growth, and even possibly protecting against neurodegenerative disorders. While also detected in Durban Poison and Doug’s Varin, among other strains, THCV predominantly appears in African sativas and has started being isolated for use in both tinctures and edibles.
