Rising delta-9-tetrahydrocannabinol (THC) levels in cannabis have made high potency use a key policy concern. Its health impact remains unclear.
Researchers conducted a retrospective study reviewing observational and experimental studies on high-potency cannabis use and health outcomes.
They obtained records from five biomedical databases and categorized THC potency (1%–9%, 10%–19%, 20%–30%, kief/resin ∼30%–50%, concentrates ≥60%). A landmark report determined outcome eligibility. About 2 reviewers independently screened, selected, extracted, and assessed quality. Findings were synthesized using quantitative and narrative methods, with certainty assessed via Grading of Recommendations, Assessment, Development, and Evaluations (GRADE).