Both major cannabis compounds, CBD and THC, may interact with some medications, which could affect their efficiency and increase the side effects of taking the medications. As such, there is a need to understand all these interactions and how they could affect your health.
Both compounds undergo hepatic metabolism via the cytochrome P450 enzyme system; major participating enzymes include CYP3A4 and CYP2C9. Many of these same enzymes are involved in the metabolism of a multitude of prescription medications, including blood thinners like warfarin, certain antidepressants, antiepileptic drugs, and some cholesterol-lowering medications. When CBD or THC is introduced, they may inhibit or compete for these enzymes, increasing or decreasing respective medication levels in the blood.
As an example, CBD increases the action of blood thinners, thus increasing the possibility of bleeding. THC also can increase the action of sedatives or anti-anxiety medications and lead to an increased state of sedation. The use of cannabis products with alcohol or other substances that affect the central nervous system may also result in an increased potential for drowsiness or a decreased mental capacity.
It is also very important to consider that certain medications have psychoactive effects, like antipsychotics or mood stabilizers. These can interact in an unpredictable manner with THC.
Because of the complication that might arise, always consult your health professional before mixing CBD or THC with your medication. This will help them assess any potential drug interaction and adjust dosages to maintain your safety and well-being. While cannabis offers many therapeutic benefits, it’s vital to use it responsibly alongside other treatments.
